| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor UFO |
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| Ligand | BDBM397074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Autophosphorylation Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as tam inhibitors US Patent US9981975 Publication Date 5/29/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor UFO |
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| Name: | Tyrosine-protein kinase receptor UFO |
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| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 98316.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30530 |
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| Residue: | 894 |
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| Sequence: | MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
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| BDBM397074 |
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| n/a |
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| Name | BDBM397074 |
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| Synonyms: | US10442810, Example 137 | US10844069, Example 137 | US11591338, Example 137 | US9981975, Example 137 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H38N8O4 |
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| Mol. Mass. | 658.7488 |
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| SMILES | CCOCc1c(cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n1-c1ccccc1)C#N |
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| Structure | 
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