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TargetBeta-secretase 1 [22-457]
LigandBDBM32388
Substrate/CompetitorBACE Substrate Peptide
Meas. Tech.Enzyme Inhibition Assay
Temperature298.15±n/a K
IC50>250000±n/a nM
Commentsextracted
Citation Blum, A; Böttcher, J; Sammet, B; Luksch, T; Heine, A; Klebe, G; Diederich, WE Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem16:8574-86 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Beta-secretase 1 [22-457]
Name:Beta-secretase 1 [22-457]
Synonyms:Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1)
Type:Extracellular Domain
Mol. Mass.:48425.17
Organism:Homo sapiens (Human)
Description:Recombinant beta-secretase was purchased from Sigma.
Residue:436
Sequence:
TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTV
GSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSL
VKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYE
VIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDG
FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCY
KFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
DCGYNIPQTDESTLMT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM32388
BACE Substrate Peptide
Name:BACE Substrate Peptide
Synonyms:n/a
Type:fluorogenic substrate
Mol. Mass.:5746.92
Organism:n/a
Description:n/a
Residue:54
Sequence:
MOCAc-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-(2,4-dinitroph
enyl)-Lys-Arg-Arg-NH2