| Reaction Details |
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 | Report a problem with these data |
| Target | Dimer of Gag-Pol polyprotein [501-599] |
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| Ligand | BDBM17349 |
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| Substrate/Competitor | Chromogenic peptide substrate |
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| Meas. Tech. | Protease Inhibition Assay |
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| pH | 4.7±n/a |
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| Ki | 33±n/a nM |
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| Citation |  Skalova, T; Hasek, J; Dohnalek, J; Petrokova, H; Buchtelova, E; Duskova, J; Soucek, M; Majer, P; Uhlikova, T; Konvalinka, J An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study. J Med Chem46:1636-44 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| |
| Dimer of Gag-Pol polyprotein [501-599] |
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| Name: | Dimer of Gag-Pol polyprotein [501-599] |
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| Synonyms: | HIV-1 Protease |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [501-599] |
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| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10795.19 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03367[501-599] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| Component 2 |
| Name: | Gag-Pol polyprotein [501-599] |
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| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10795.19 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03367[501-599] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM17349 |
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| Chromogenic peptide substrate |
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| Name: | Chromogenic peptide substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 2942.29 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 28 |
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| Sequence: | Lys-Ala-Arg-Val-Nle*Nph-Glu-Ala-Nle-NH2
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