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TargetSignal transducer and activator of transcription 1-alpha/beta
LigandBDBM43504
Substrate/Competitorn/a
Meas. Tech.Dose response cell-based assay to measure STAT1 inhibition
IC50>55700±n/a nM
Citation PubChem, PC Dose response cell-based assay to measure STAT1 inhibition PubChem Bioassay(2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Signal transducer and activator of transcription 1-alpha/beta
Name:Signal transducer and activator of transcription 1-alpha/beta
Synonyms:STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:Cytosolic Transcription Factor
Mol. Mass.:87327.69
Organism:Homo sapiens (Human)
Description:Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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  Blast E-value cutoff:
BDBM43504
n/a
NameBDBM43504
Synonyms:5-amino-3-(2-methylphenyl)-1,2-oxazole-4-carbonitrile | 5-amino-3-(2-methylphenyl)-4-isoxazolecarbonitrile | 5-amino-3-(2-methylphenyl)isoxazole-4-carbonitrile | 5-amino-3-(o-tolyl)isoxazole-4-carbonitrile | 5-azanyl-3-(2-methylphenyl)-1,2-oxazole-4-carbonitrile | MLS000045809 | SMR000028206 | cid_3236239
TypeSmall organic molecule
Emp. Form.C11H9N3O
Mol. Mass.199.2087
SMILESCc1ccccc1-c1noc(N)c1C#N
Structure
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