| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 12 member 5 |
|---|
| Ligand | BDBM43941 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 |
|---|
| EC50 | 733±n/a nM |
|---|
| Citation |  PubChem, PC Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Solute carrier family 12 member 5 |
|---|
| Name: | Solute carrier family 12 member 5 |
|---|
| Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 126185.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_828024 |
|---|
| Residue: | 1139 |
|---|
| Sequence: | MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
|
|
|
|---|
| BDBM43941 |
|---|
| n/a |
|---|
| Name | BDBM43941 |
|---|
| Synonyms: | 4-(2-benzo[cd]indolylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone | 4-(benzo[cd]indol-2-ylamino)-1,5-dimethyl-2-phenyl-3-pyrazolin-3-one | 4-(benzo[cd]indol-2-ylamino)-1,5-dimethyl-2-phenyl-pyrazol-3-one | 4-(benzo[cd]indol-2-ylamino)-1,5-dimethyl-2-phenylpyrazol-3-one | MLS000057557 | SMR000060636 | cid_2323143 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H18N4O |
|---|
| Mol. Mass. | 354.4045 |
|---|
| SMILES | Cc1c(N=C2Nc3cccc4cccc2c34)c(=O)n(-c2ccccc2)n1C |w:3.2| |
|---|
| Structure | 
|
|---|
Search and Browse
