| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM48078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency |
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| EC50 | 5810±n/a nM |
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| Citation |  PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52841.70 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
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| Residue: | 477 |
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| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM48078 |
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| n/a |
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| Name | BDBM48078 |
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| Synonyms: | 3-amino-4-methyl-6-(2-morpholin-4-ylethoxy)-N-phenylthieno[2,3-b]pyridine-2-carboxamide | 3-amino-4-methyl-6-(2-morpholinoethoxy)-N-phenyl-thieno[2,3-b]pyridine-2-carboxamide | 3-amino-4-methyl-6-[2-(4-morpholinyl)ethoxy]-N-phenyl-2-thieno[2,3-b]pyridinecarboxamide | 3-azanyl-4-methyl-6-(2-morpholin-4-ylethoxy)-N-phenyl-thieno[2,3-b]pyridine-2-carboxamide | VU0359455 | cid_45142489 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N4O3S |
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| Mol. Mass. | 412.505 |
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| SMILES | Cc1cc(OCCN2CCOCC2)nc2sc(C(=O)Nc3ccccc3)c(N)c12 |
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| Structure | 
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