Reaction Details |
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Target | Kappa-type opioid receptor |
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Ligand | BDBM60248 |
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Substrate/Competitor | n/a |
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Meas. Tech. | uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay |
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IC50 | 5000±n/a nM |
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Citation | PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Kappa-type opioid receptor |
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Name: | Kappa-type opioid receptor |
Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 42648.76 |
Organism: | Homo sapiens (Human) |
Description: | P41145 |
Residue: | 380 |
Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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BDBM60248 |
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n/a |
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Name | BDBM60248 |
Synonyms: | MLS000729783 | N-[1-(cyclohexylcarbamoyl)cyclohexyl]-N-(2-thenyl)picolinamide | N-[1-(cyclohexylcarbamoyl)cyclohexyl]-N-(thiophen-2-ylmethyl)pyridine-2-carboxamide | N-[1-[(cyclohexylamino)-oxomethyl]cyclohexyl]-N-(thiophen-2-ylmethyl)-2-pyridinecarboxamide | N-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-N-(thien-2-ylmethyl)pyridine-2-carboxamide | SMR000308060 | cid_5236771 |
Type | Small organic molecule |
Emp. Form. | C24H31N3O2S |
Mol. Mass. | 425.587 |
SMILES | O=C(NC1CCCCC1)C1(CCCCC1)N(Cc1cccs1)C(=O)c1ccccn1 |
Structure |
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