| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 23640±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61259 |
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| n/a |
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| Name | BDBM61259 |
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| Synonyms: | 4-[3-[(5E)-5-(4-ethoxybenzylidene)-4-keto-2-thioxo-thiazolidin-3-yl]propanoylamino]benzoic acid | 4-[3-[(5E)-5-[(4-ethoxyphenyl)methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoylamino]benzoic acid | 4-[3-[(5E)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoylamino]benzoic acid | 4-[[3-[(5E)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]-1-oxopropyl]amino]benzoic acid | MLS001201637 | SMR000806146 | cid_1580466 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N2O5S2 |
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| Mol. Mass. | 456.535 |
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| SMILES | CCOc1ccc(\C=C2\SC(=S)N(CCC(=O)Nc3ccc(cc3)C(O)=O)C2=O)cc1 |
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| Structure | 
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