| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM40234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. |
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| IC50 | >108803±n/a nM |
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| Citation |  PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM40234 |
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| n/a |
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| Name | BDBM40234 |
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| Synonyms: | 3-(4-Ethoxy-phenyl)-7-furan-2-yl-5-oxo-3,4,6,7-tetrahydro-2H,5H-1-thia-3,4a-diaza-naphthalene-8-carb onitrile | 3-(4-ethoxyphenyl)-8-(2-furanyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | 3-(4-ethoxyphenyl)-8-(furan-2-yl)-6-oxidanylidene-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | 3-(4-ethoxyphenyl)-8-(furan-2-yl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | 8-(2-furyl)-6-keto-3-p-phenetyl-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | MLS000559219 | SMR000149535 | cid_4888547 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O3S |
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| Mol. Mass. | 381.448 |
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| SMILES | CCOc1ccc(cc1)N1CSC2=C(C#N)C(CC(=O)N2C1)c1ccco1 |c:13| |
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| Structure | 
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