Reaction Details |
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Target | Eukaryotic translation initiation factor 2-alpha kinase 3 |
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Ligand | BDBM102213 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Alpha Elisa Assay |
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IC50 | 55±n/a nM |
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Citation | Bifulco, Jr., N; DiPietro, LV; Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent US9695165 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic translation initiation factor 2-alpha kinase 3 |
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Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
Synonyms: | E2AK3_HUMAN | EIF2AK3 | HsPEK | PEK | PERK | Pancreatic eIF2-alpha kinase | Pancreatic endoplasmic reticulum kinase (PERK) |
Type: | Enzyme |
Mol. Mass.: | 125190.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NZJ5 |
Residue: | 1116 |
Sequence: | MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
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BDBM102213 |
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n/a |
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Name | BDBM102213 |
Synonyms: | US9695165, 18 |
Type | Small organic molecule |
Emp. Form. | C27H20Cl2FN3O3 |
Mol. Mass. | 524.37 |
SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C |
Structure |
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