Ki Summary

Reaction Details

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Target

Eukaryotic translation initiation factor 2-alpha kinase 3

Ligand

BDBM102277

Substrate/Competitor

n/a

Meas. Tech.

Alpha Elisa Assay

IC50

55±n/a nM

Citation

Bifulco, Jr., N; DiPietro, LV; Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent US9695165 Publication Date 7/4/2017

More Info.:

Get all data from this article, Assay Method

Eukaryotic translation initiation factor 2-alpha kinase 3

Name:

Eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms:

Type:

Enzyme

Mol. Mass.:

125190.66

Organism:

Homo sapiens (Human)

Description:

Q9NZJ5

Residue:

1116

Sequence:

MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN

BDBM102277

n/a

Name

BDBM102277

Synonyms:

US9695165, 25

Type

Small organic molecule

Emp. Form.

C28H25Cl2N3O4

Mol. Mass.

538.422

SMILES

COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)|

Structure