Ki Summary

Reaction Details

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Target

Eukaryotic translation initiation factor 2-alpha kinase 3

Ligand

BDBM103852

Substrate/Competitor

n/a

Meas. Tech.

Alpha Elisa Assay

IC50

55±n/a nM

Citation

Bifulco, Jr., N; DiPietro, LV; Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent US9695165 Publication Date 7/4/2017

More Info.:

Get all data from this article, Assay Method

Eukaryotic translation initiation factor 2-alpha kinase 3

Name:

Eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms:

Type:

Enzyme

Mol. Mass.:

125190.66

Organism:

Homo sapiens (Human)

Description:

Q9NZJ5

Residue:

1116

Sequence:

MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN

BDBM103852

n/a

Name

BDBM103852

Synonyms:

US9695165, 35

Type

Small organic molecule

Emp. Form.

C28H24Cl2N4O4

Mol. Mass.

551.421

SMILES

CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCN(C(=O)C=C)c2c1 |(5.19,.45,;3.86,-.32,;2.53,.45,;1.19,-.32,;1.19,-1.86,;-.14,-2.63,;-1.47,-1.86,;-1.47,-.32,;-.14,.45,;-.14,1.99,;1.19,2.76,;1.19,4.3,;-.14,5.07,;-1.47,4.3,;-.14,6.61,;-1.47,7.38,;-2.81,6.61,;1.19,7.38,;2.53,6.61,;3.86,7.38,;3.86,8.92,;2.53,5.07,;3.86,4.3,;2.53,1.99,;3.86,2.76,;-.14,-4.17,;1.19,-4.94,;1.19,-6.48,;-.14,-7.25,;-.46,-8.76,;-1.99,-8.92,;-2.62,-7.51,;-4.11,-7.11,;-5.19,-8.2,;-4.5,-5.63,;-3.42,-4.54,;-1.47,-6.48,;-1.47,-4.94,)|

Structure