Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 7

Ligand

BDBM62217

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao for SAR Compounds

EC50

67±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao for SAR Compounds PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 7

Name:

Regulator of G-protein signaling 7

Synonyms:

RGS7 | RGS7_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57675.72

Organism:

Homo sapiens (Human)

Description:

P49802

Residue:

495

Sequence:

MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGS
DIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNC
WEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKK
RDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSH
SPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPP
DPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENL
RFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFE
DAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPC
HKNCTPTLRASTNLL

BDBM62217

n/a

Name

BDBM62217

Synonyms:

2,4-dimethyl-6-[2-oxidanylidene-2-(4-phenylpiperazin-1-yl)ethyl]-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1,6-naphthyridin-5-one | 6-[2-keto-2-(4-phenylpiperazino)ethyl]-2,4-dimethyl-1,6-naphthyridin-5-one | KUC103672N | cid_44473128

Type

Small organic molecule

Emp. Form.

C22H24N4O2

Mol. Mass.

376.4516

SMILES

Cc1cc(C)c2c(ccn(CC(=O)N3CCN(CC3)c3ccccc3)c2=O)n1

Structure