| Reaction Details |
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 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
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| Ligand | BDBM33125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
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| IC50 | 590±n/a nM |
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| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA damage-inducible transcript 3 protein |
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| Name: | DNA damage-inducible transcript 3 protein |
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| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 19175.17 |
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| Organism: | Mus musculus |
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| Description: | gi_160707929 |
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| Residue: | 168 |
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| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
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| BDBM33125 |
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| n/a |
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| Name | BDBM33125 |
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| Synonyms: | 2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxidanylidene-3-thiophen-2-yl-prop-1-en-2-yl]pyridin-2-ylidene]propanedinitrile | 2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxo-3-thiophen-2-ylprop-1-en-2-yl]-2-pyridinylidene]propanedinitrile | 2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxo-3-thiophen-2-ylprop-1-en-2-yl]pyridin-2-ylidene]propanedinitrile | 2-[1-[(Z)-2-(4-methoxyphenyl)-1-(2-thenoyl)vinyl]-2-pyridylidene]malononitrile | MLS000418543 | SMR000265055 | cid_6019083 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15N3O2S |
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| Mol. Mass. | 385.438 |
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| SMILES | COc1ccc(\C=C(/N2C=CC=CC2=C(C#N)C#N)C(=O)c2cccs2)cc1 |c:9,11| |
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| Structure | 
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