Ki Summary

Reaction Details

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Target

Mitochondrial import inner membrane translocase subunit TIM10

Ligand

BDBM78214

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay

IC50

19300±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mitochondrial import inner membrane translocase subunit TIM10

Name:

Mitochondrial import inner membrane translocase subunit TIM10

Synonyms:

MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...

Type:

Enzyme Catalytic Domain

Mol. Mass.:

10303.50

Organism:

Saccharomyces cerevisiae S288c

Description:

gi_285809906

Residue:

Sequence:

MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESS
CLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF

BDBM78214

n/a

Name

BDBM78214

Synonyms:

2-[2-[4-(2-hydroxy-3-naphthalen-2-yloxypropyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-(3-naphthalen-2-yloxy-2-oxidanyl-propyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-[2-hydroxy-3-(2-naphthalenyloxy)propyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-[2-hydroxy-3-(2-naphthoxy)propyl]piperazino]ethyl]benzo[de]isoquinoline-1,3-quinone | MLS000723312 | SMR000236439 | cid_4100896

Type

Small organic molecule

Emp. Form.

C31H31N3O4

Mol. Mass.

509.5955

SMILES

OC(COc1ccc2ccccc2c1)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1

Structure