Ki Summary

Reaction Details

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Target

Ubiquitin-conjugating enzyme E2 N

Ligand

BDBM78934

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay

IC50

>20000±0 nM

Citation

PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Ubiquitin-conjugating enzyme E2 N

Name:

Ubiquitin-conjugating enzyme E2 N

Synonyms:

BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N

Type:

PROTEIN

Mol. Mass.:

17137.61

Organism:

Homo sapiens (Human)

Description:

EBI_101440

Residue:

152

Sequence:

MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE
EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP
LANDVAEQWKTNEAQAIETARAWTRLYAMNNI

BDBM78934

n/a

Name

BDBM78934

Synonyms:

2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride | 2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] ester;hydrate;hydrochloride | MLS001056800 | Mibefradil dihydrochloride hydrate | SMR000326970 | US11130750, Example Mibefradil | [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoranyl-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyethanoate;hydrate;hydrochloride | [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate;hydrate;hydrochloride | cid_16746591

Type

Small organic molecule

Emp. Form.

C29H38FN3O3

Mol. Mass.

495.6287

SMILES

COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C

Structure