| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM41443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format |
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| IC50 | 4990±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM41443 |
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| n/a |
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| Name | BDBM41443 |
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| Synonyms: | MLS000060380 | N-(2,5-diethoxy-4-morpholin-4-yl-phenyl)-2-quinolin-8-yloxy-ethanamide | N-(2,5-diethoxy-4-morpholin-4-ylphenyl)-2-quinolin-8-yloxyacetamide | N-(2,5-diethoxy-4-morpholino-phenyl)-2-(8-quinolyloxy)acetamide | N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]-2-(8-quinolinyloxy)acetamide | SMR000066251 | cid_2997882 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N3O5 |
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| Mol. Mass. | 451.5149 |
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| SMILES | CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)COc1cccc2cccnc12 |
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| Structure | 
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