| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
|---|
| Ligand | BDBM270627 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Jak Biochemical HTRF Assay Protocol |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 720±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Dinsmore, C; Fuller, P; Guerin, D; Katz, JD; Thompson, CF; Falcone, D; Deng, W; Torres, L; Zeng, H; Bai, Y; Fu, J; Kong, N; Liu, Y; Zheng, Z; Scott, ME Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors US Patent US10059705 Publication Date 8/28/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 |
|---|
| Name: | Tyrosine-protein kinase JAK2 |
|---|
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 130684.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM270627 |
|---|
| n/a |
|---|
| Name | BDBM270627 |
|---|
| Synonyms: | US10059705, II-22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N5O3S |
|---|
| Mol. Mass. | 409.462 |
|---|
| SMILES | O=c1[nH]ccc2n(nc(Nc3ccc4c(CCS4(=O)=O)c3)c12)[C@@H](CC#N)C1CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
