| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50071058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| Temperature | 310.15±0 K |
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| IC50 | 1.6e+3± 4e+2 nM |
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| Citation |  King, AR; Dotsey, EY; Lodola, A; Jung, KM; Ghomian, A; Qiu, Y; Fu, J; Mor, M; Piomelli, D Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol16:1045-52 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL) |
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| Type: | Enzyme |
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| Mol. Mass.: | 33505.38 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q8R431 |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
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| BDBM50071058 |
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| n/a |
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| Name | BDBM50071058 |
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| Synonyms: | (2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid | CELASTROL | CHEMBL301982 | cid_4274774 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38O4 |
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| Mol. Mass. | 450.6096 |
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| SMILES | C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17| |
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| Structure | 
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