| Reaction Details |
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 | Report a problem with these data |
| Target | Endoribonuclease toxin MazF |
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| Ligand | BDBM75025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay |
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| EC50 | >99000±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoribonuclease toxin MazF |
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| Name: | Endoribonuclease toxin MazF |
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| Synonyms: | MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12100.43 |
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| Organism: | Escherichia coli str. K-12 substr. MG1655 |
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| Description: | gi_16130689 |
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| Residue: | 111 |
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| Sequence: | MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPF
EVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
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| BDBM75025 |
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| n/a |
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| Name | BDBM75025 |
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| Synonyms: | 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-5-pyrimidinecarbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxidanylidene-pyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxopyrimidine-5-carbonitrile | 4-[4-(dimethylamino)phenyl]-6-keto-1-methyl-2-(methylthio)pyrimidine-5-carbonitrile | MLS000766800 | SMR000339696 | cid_694212 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N4OS |
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| Mol. Mass. | 300.379 |
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| SMILES | CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C |
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| Structure | 
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