Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50005848

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_138135

6300±n/a nM

Citation

Nordvall, G; Sundquist, S; Glas, G; Gogoll, A; Nilvebrant, L; Hacksell, U Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. J Med Chem35:1541-50 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1

Type:

Protein

Mol. Mass.:

51442.54

Organism:

Homo sapiens (Human)

Description:

P11229

Residue:

460

Sequence:

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50005848

n/a

Name

BDBM50005848

Synonyms:

(2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | (2'S)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | 2'-methyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,4'-(dihydro[1,3]dioxolane)] | CHEMBL291280

Type

Small organic molecule

Emp. Form.

C10H17NO2

Mol. Mass.

183.2475

SMILES

C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|

Structure