| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Ligand | BDBM50266410 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1700822 (CHEMBL4051804) |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Salah, M; Abdelsamie, AS; Frotscher, M First Dual Inhibitors of Steroid Sulfatase (STS) and 17?-Hydroxysteroid Dehydrogenase Type 1 (17?-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. J Med Chem60:4086-4092 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
|---|
| Type: | Oxidoreductase; single-pass type II membrane protein |
|---|
| Mol. Mass.: | 42795.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Enzyme was partially purified from human placenta. |
|---|
| Residue: | 387 |
|---|
| Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
|
|
|
|---|
| BDBM50266410 |
|---|
| n/a |
|---|
| Name | BDBM50266410 |
|---|
| Synonyms: | CHEMBL4064200 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H10ClF2NO5S2 |
|---|
| Mol. Mass. | 445.845 |
|---|
| SMILES | NS(=O)(=O)Oc1ccc(-c2ccc(s2)C(=O)c2c(F)ccc(O)c2F)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
