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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50266876
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1701465 (CHEMBL4052447)
Ki 58±n/a nM
Citation Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem60:4234-4244 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM50266876
n/a
NameBDBM50266876
Synonyms:CHEMBL4093959
TypeSmall organic molecule
Emp. Form.C35H33Cl2FN4O5
Mol. Mass.679.565
SMILESOC(=O)CCC(=O)NCCCCCCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(9.15,-11.62,;9.92,-12.95,;9.15,-14.28,;11.46,-12.95,;12.23,-14.28,;13.77,-14.28,;14.54,-12.95,;14.54,-15.62,;16.08,-15.62,;16.85,-16.95,;18.39,-16.95,;19.16,-18.29,;20.7,-18.29,;21.47,-19.62,;23.01,-19.62,;23.78,-18.29,;23.01,-16.95,;25.32,-18.29,;26.23,-19.53,;27.69,-19.06,;29.02,-19.83,;30.36,-19.06,;31.69,-19.83,;30.36,-17.52,;29.02,-16.75,;27.69,-17.52,;26.23,-17.04,;25.75,-15.57,;26.65,-14.33,;25.75,-13.08,;24.28,-13.56,;24.28,-15.1,;23.04,-16,;21.63,-15.38,;20.39,-16.28,;18.98,-15.66,;18.82,-14.12,;17.41,-13.49,;20.07,-13.22,;21.47,-13.85,;28.19,-14.33,;28.96,-13,;30.5,-13,;31.27,-14.33,;32.81,-14.33,;30.5,-15.66,;28.96,-15.66,)|
Structure
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