Reaction Details |
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Target | Neuronal acetylcholine receptor subunit beta-2/beta-4 |
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Ligand | BDBM50270390 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1708058 (CHEMBL4059291) |
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IC50 | 24000±n/a nM |
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Citation | Crestey, F; Jensen, AA; Soerensen, C; Magnus, CB; Andreasen, JT; Peters, GHJ; Kristensen, JL Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. J Med Chem61:1719-1729 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit beta-2/beta-4 |
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Name: | Neuronal acetylcholine receptor subunit beta-2/beta-4 |
Synonyms: | Nicotinic acetylcholine receptor alpha-4/beta-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1335312 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Neuronal acetylcholine receptor subunit beta-4 |
Synonyms: | ACHB4_MOUSE | Acrb4 | Chrnb4 |
Type: | PROTEIN |
Mol. Mass.: | 55814.93 |
Organism: | Mus musculus |
Description: | ChEMBL_108396 |
Residue: | 495 |
Sequence: | MRGTPLLLVSLFALLQPGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELS
LSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNA
DGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEI
DMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLII
PCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLF
TMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSPARVPH
SSQLHLTTAEATSTSALGPSSPSNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSS
GRFRQDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGL
FLPPLFQIHAPSKGL
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Component 2 |
Name: | Neuronal acetylcholine receptor subunit beta-2 |
Synonyms: | ACHB2_MOUSE | Chrnb2 |
Type: | PROTEIN |
Mol. Mass.: | 57114.19 |
Organism: | Mus musculus |
Description: | ChEMBL_108396 |
Residue: | 501 |
Sequence: | MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLY
NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
TEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQR
LRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCS
CGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQP
LFQNYTATTFLHSDHSAPSSK
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BDBM50270390 |
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n/a |
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Name | BDBM50270390 |
Synonyms: | CHEMBL4062419 |
Type | Small organic molecule |
Emp. Form. | C18H21NO2 |
Mol. Mass. | 283.3648 |
SMILES | COc1cc2CN(C)CCc2cc1OCc1ccccc1 |
Structure |
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