| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
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| Ligand | BDBM313806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1728754 (CHEMBL4144032) |
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| IC50 | 370±n/a nM |
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| Citation |  Sharp, PP; Garnier, JM; Hatfaludi, T; Xu, Z; Segal, D; Jarman, KE; Jousset, H; Garnham, A; Feutrill, JT; Cuzzupe, A; Hall, P; Taylor, S; Walkley, CR; Tyler, D; Dawson, MA; Czabotar, P; Wilks, AF; Glaser, S; Huang, DCS; Burns, CJ Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors. ACS Med Chem Lett8:1298-1303 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 2 |
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| Name: | Bromodomain-containing protein 2 |
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| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
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| Type: | Protein |
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| Mol. Mass.: | 88085.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25440 |
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| Residue: | 801 |
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| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
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| BDBM313806 |
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| n/a |
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| Name | BDBM313806 |
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| Synonyms: | US10167292, Example 50 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16ClF3N4O |
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| Mol. Mass. | 408.805 |
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| SMILES | Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(O)C(F)(F)F |
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| Structure | 
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