| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-U receptor 1 |
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| Ligand | BDBM50291730 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1731399 (CHEMBL4146935) |
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| IC50 | 0.290000±n/a nM |
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| Citation |  De Prins, A; Martin, C; Van Wanseele, Y; Skov, LJ; Tömböly, C; Tourwé, D; Caveliers, V; Van Eeckhaut, A; Holst, B; Rosenkilde, MM; Smolders, I; Ballet, S Development of potent and proteolytically stable human neuromedin U receptor agonists. Eur J Med Chem144:887-897 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-U receptor 1 |
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| Name: | Neuromedin-U receptor 1 |
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| Synonyms: | G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | GPR66 | NMU-R1 | NMUR1 | NMUR1_HUMAN | Neuromedin-U receptor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47370.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103121 |
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| Residue: | 426 |
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| Sequence: | MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELF
MPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYE
MWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRR
VLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFF
CLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLF
VLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMS
SRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQ
QETDPS
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| BDBM50291730 |
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| n/a |
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| Name | BDBM50291730 |
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| Synonyms: | CHEMBL4169726 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H80N16O11 |
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| Mol. Mass. | 1153.335 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| |
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| Structure | 
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