Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM50292422 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1732723 (CHEMBL4148259) |
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IC50 | 33860±n/a nM |
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Citation | Dias Viegas, FP; de Freitas Silva, M; Divino da Rocha, M; Castelli, MR; Riquiel, MM; Machado, RP; Vaz, SM; Simões de Lima, LM; Mancini, KC; Marques de Oliveira, PC; Morais, ÉP; Gontijo, VS; da Silva, FMR; D'Alincourt da Fonseca Peçanha, D; Castro, NG; Neves, GA; Giusti-Paiva, A; Vilela, FC; Orlandi, L; Camps, I; Veloso, MP; Leomil Coelho, LF; Ionta, M; Ferreira-Silva, GÁ; Pereira, RM; Dardenne, LE; Guedes, IA; de Oliveira Carneiro Junior, W; Quaglio Bellozi, PM; Pinheiro de Oliveira, AC; Ferreira, FF; Pruccoli, L; Tarozzi, A; Viegas, C Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. Eur J Med Chem147:48-65 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
Type: | Enzyme |
Mol. Mass.: | 65643.35 |
Organism: | Equus caballus (Horse) |
Description: | P81908 |
Residue: | 574 |
Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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BDBM50292422 |
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n/a |
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Name | BDBM50292422 |
Synonyms: | CHEMBL4175724 |
Type | Small organic molecule |
Emp. Form. | C20H22N4O4 |
Mol. Mass. | 382.4131 |
SMILES | OC1CCCN(Cc2ccc(cc2)C(=O)N\N=C\c2ccc(cc2)[N+]([O-])=O)C1 |
Structure |
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