| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50408220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739430 (CHEMBL4155180) |
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| IC50 | >10000±n/a nM |
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| Citation |  Chicca, A; Arena, C; Bertini, S; Gado, F; Ciaglia, E; Abate, M; Digiacomo, M; Lapillo, M; Poli, G; Bifulco, M; Macchia, M; Tuccinardi, T; Gertsch, J; Manera, C Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system. Eur J Med Chem154:155-171 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50408220 |
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| n/a |
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| Name | BDBM50408220 |
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| Synonyms: | CHEMBL4175577 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25FN2O2 |
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| Mol. Mass. | 356.4338 |
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| SMILES | Cc1ccn(Cc2ccc(F)cc2)c(=O)c1C(=O)NC1CCCCCC1 |
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| Structure | 
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