Reaction Details |
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Target | NAD-dependent protein deacylase sirtuin-6 |
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Ligand | BDBM50451275 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1744886 (CHEMBL4179396) |
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IC50 | 22000±n/a nM |
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Citation | Damonte, P; Sociali, G; Parenti, MD; Soncini, D; Bauer, I; Boero, S; Grozio, A; Holtey, MV; Piacente, F; Becherini, P; Sanguineti, R; Salis, A; Damonte, G; Cea, M; Murone, M; Poggi, A; Nencioni, A; Del Rio, A; Bruzzone, S SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem25:5849-5858 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacylase sirtuin-6 |
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Name: | NAD-dependent protein deacylase sirtuin-6 |
Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
Type: | Protein |
Mol. Mass.: | 39133.03 |
Organism: | Homo sapiens (Human) |
Description: | Q8N6T7 |
Residue: | 355 |
Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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BDBM50451275 |
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n/a |
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Name | BDBM50451275 |
Synonyms: | CHEMBL4205716 |
Type | Small organic molecule |
Emp. Form. | C19H14N2O6 |
Mol. Mass. | 366.3243 |
SMILES | OC(=O)c1ccc(NC(=O)c2ccc(NC(=O)c3ccco3)cc2)cc1O |
Structure |
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