| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50304793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1745981 (CHEMBL4180491) |
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| Ki | 2.0±n/a nM |
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| Citation |  Silva, DG; Ribeiro, JFR; De Vita, D; Cianni, L; Franco, CH; Freitas-Junior, LH; Moraes, CB; Rocha, JR; Burtoloso, ACB; Kenny, PW; Leitão, A; Montanari, CA A comparative study of warheads for design of cysteine protease inhibitors. Bioorg Med Chem Lett27:5031-5035 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50304793 |
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| n/a |
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| Name | BDBM50304793 |
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| Synonyms: | (S)-benzyl 1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate | CHEMBL604281 | acs.jmedchem.1c00409_ST.400 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O3 |
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| Mol. Mass. | 366.4137 |
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| SMILES | CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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