Reaction Details |
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Target | NACHT, LRR and PYD domains-containing protein 3 |
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Ligand | BDBM50155926 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1752784 (CHEMBL4187544) |
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IC50 | 5.0±n/a nM |
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Citation | Salla, M; Butler, MS; Massey, NL; Reid, JC; Cooper, MA; Robertson, AAB Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorg Med Chem Lett28:793-795 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NACHT, LRR and PYD domains-containing protein 3 |
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Name: | NACHT, LRR and PYD domains-containing protein 3 |
Synonyms: | C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 118173.88 |
Organism: | Homo sapiens (Human) |
Description: | Q96P20 |
Residue: | 1036 |
Sequence: | MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
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BDBM50155926 |
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n/a |
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Name | BDBM50155926 |
Synonyms: | CHEMBL3183703 |
Type | Small organic molecule |
Emp. Form. | C20H24N2O5S |
Mol. Mass. | 404.48 |
SMILES | CC(C)(O)c1coc(c1)S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12 |
Structure |
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