Reaction Details |
| Report a problem with these data |
Target | Folate receptor beta |
---|
Ligand | BDBM50457431 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1759623 (CHEMBL4194631) |
---|
IC50 | 839±n/a nM |
---|
Citation | Ravindra, M; Wallace-Povirk, A; Karim, MA; Wilson, MR; O'Connor, C; White, K; Kushner, J; Polin, L; George, C; Hou, Z; Matherly, LH; Gangjee, A Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem61:2027-2040 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Folate receptor beta |
---|
Name: | Folate receptor beta |
Synonyms: | FBP | FOLR2 | FOLR2_HUMAN | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein |
Type: | PROTEIN |
Mol. Mass.: | 29286.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_20077 |
Residue: | 255 |
Sequence: | MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACC
TASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRK
ERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPA
ALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGG
LLLSLALMLQLWLLG
|
|
|
BDBM50457431 |
---|
n/a |
---|
Name | BDBM50457431 |
Synonyms: | CHEMBL4218109 |
Type | Small organic molecule |
Emp. Form. | C21H20N6O6 |
Mol. Mass. | 452.4201 |
SMILES | Nc1nc2[nH]c(CCC#Cc3ccc(cn3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
Structure |
|