| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
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| Ligand | BDBM50229711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767820 (CHEMBL4219932) |
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| EC50 | 268±n/a nM |
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| Citation |  Cioffi, CL Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. J Med Chem61:2652-2679 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-1 |
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| Name: | Glycine receptor subunit alpha-1 |
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| Synonyms: | GLRA1_MOUSE | Glra1 | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit | Glycine receptor subunit alpha-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52669.43 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_118105 |
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| Residue: | 457 |
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| Sequence: | MYSFNTLRFYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
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| BDBM50229711 |
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| n/a |
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| Name | BDBM50229711 |
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| Synonyms: | CHEMBL4074873 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O4S |
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| Mol. Mass. | 383.421 |
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| SMILES | [H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r| |
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| Structure | 
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