| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
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| Ligand | BDBM50459970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767835 (CHEMBL4219947) |
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| EC50 | 0.430000±n/a nM |
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| Citation |  Cioffi, CL Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. J Med Chem61:2652-2679 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-1 |
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| Name: | Glycine receptor subunit alpha-1 |
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| Synonyms: | GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52635.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23415 |
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| Residue: | 457 |
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| Sequence: | MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
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| BDBM50459970 |
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| n/a |
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| Name | BDBM50459970 |
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| Synonyms: | CHEMBL4227297 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22FNO2 |
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| Mol. Mass. | 279.3498 |
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| SMILES | CC(C)c1cc(cc(C(C)C)c1O)C(=O)N1CC(F)C1 |
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| Structure | 
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