| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 3 |
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| Ligand | BDBM50463033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1777047 (CHEMBL4234039) |
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| IC50 | >10000±n/a nM |
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| Citation |  Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg Med Chem26:4209-4224 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 3 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 3 |
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| Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56886.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881455 |
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| Residue: | 518 |
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| Sequence: | MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
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| BDBM50463033 |
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| n/a |
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| Name | BDBM50463033 |
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| Synonyms: | CHEMBL4244860 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31N5O3 |
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| Mol. Mass. | 533.6202 |
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| SMILES | ON1C(=O)C(=C(C1=O)c1cn(CCCCCC#N)c2ccccc12)c1cn(CCCCCC#N)c2ccccc12 |c:4| |
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| Structure | 
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