| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 60 kDa heat shock protein, mitochondrial |
|---|
| Ligand | BDBM50468057 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1797985 (CHEMBL4270102) |
|---|
| IC50 | 26000±n/a nM |
|---|
| Citation |  Kunkle, T; Abdeen, S; Salim, N; Ray, AM; Stevens, M; Ambrose, AJ; Victorino, J; Park, Y; Hoang, QQ; Chapman, E; Johnson, SM Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus. J Med Chem61:10651-10664 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 60 kDa heat shock protein, mitochondrial |
|---|
| Name: | 60 kDa heat shock protein, mitochondrial |
|---|
| Synonyms: | 3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61050.41 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_117701 |
|---|
| Residue: | 573 |
|---|
| Sequence: | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGR
TVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLA
RSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDK
EIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQ
DAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAV
KAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKG
KGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDR
VTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIA
KNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLT
TAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
|
|
|
|---|
| BDBM50468057 |
|---|
| n/a |
|---|
| Name | BDBM50468057 |
|---|
| Synonyms: | CHEMBL4281358 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13BrN2O2S2 |
|---|
| Mol. Mass. | 457.363 |
|---|
| SMILES | Oc1c(Br)cccc1C(=O)Nc1ccc(Sc2nc3ccccc3s2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
