| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
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| Ligand | BDBM50473303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_206966 (CHEMBL817277) |
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| IC50 | 1202±n/a nM |
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| Citation |  Andersen, KE; Sørensen, JL; Lau, J; Lundt, BF; Petersen, H; Huusfeldt, PO; Suzdak, PD; Swedberg, MD Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors. J Med Chem44:2152-63 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent betaine transporter |
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| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | Na(+)/Cl(-) betaine/GABA transporter | S6A12_RAT | Slc6a12 | Sodium- and chloride-dependent betaine transporter | Solute carrier family 6 member 12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69749.57 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105007 |
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| Residue: | 614 |
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| Sequence: | MDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASY
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGR
RELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGW
LLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSP
VKQELIAWEKETHL
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| BDBM50473303 |
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| n/a |
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| Name | BDBM50473303 |
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| Synonyms: | CHEMBL542641 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30ClNO3 |
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| Mol. Mass. | 427.964 |
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| SMILES | Cl.OC(=O)C1=CN(CCOCCC2c3ccccc3CCc3ccccc23)CCC1 |t:3| |
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| Structure | 
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