Reaction Details |
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Target | 1,3-beta-glucan synthase |
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Ligand | BDBM50478215 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_472347 (CHEMBL952150) |
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IC50 | 6.2±n/a nM |
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Citation | Paderu, P; Garcia-Effron, G; Balashov, S; Delmas, G; Park, S; Perlin, DS Serum differentially alters the antifungal properties of echinocandin drugs. Antimicrob Agents Chemother51:2253-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,3-beta-glucan synthase |
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Name: | 1,3-beta-glucan synthase |
Synonyms: | GSL2 | Glucan synthase |
Type: | PROTEIN |
Mol. Mass.: | 189382.66 |
Organism: | Candida albicans |
Description: | ChEMBL_19912 |
Residue: | 1640 |
Sequence: | MFDYLMRLLDSRTSRLGPTHALRSIHADYIGGMNSNFRKWYFAAQLDIDDFVGFDNLAKN
GKIKGSNDPVATLEQAESQWSTNMLALSPTDSVIQLAIYLLIWGEANNIRFMPECICFIF
KCCNDFYFSIDPDTPVTTVTPSFLDHIITPLYNFYRDQSYILVDGKYRRRDKDHESVIGY
DDMNQLFWYSKGLERLVLADKKSRLMSLPPGERYEELNQVLWNRVFYKTFKENRGWSHVL
VNFHRVWIIHSAVFWYYTAFNSPTLYTKNYQPALDNQPTTQARLSVLAFGGVVAIVIDII
SLLFELRFIPRKWTGAQPVSKRLALLILALILNVGPSVYLFMFIPLNVQNTVGLVISAFQ
FSFSVIMVLYLSTVPLGRLFSKKPKANDRRFLPQRSFVTNFYSLAEGDRVASYGLWFAIF
VSKFIESYFFLTLSLRDPVRELSIMKMSRCAGEVWLGNWFCTRQPTIVLGLIYLTDLVLF
ILDTYLWYIVWNTVFSVCRSFYIGVSIWTPWRNIFSRLPKRIFSKIISVSGDKNIKSKLL
VSQVWNSIIISMYREHLISLEHVQKLIYKQIDNPGVEGDSVLKEPIFFVSQEDQTIKSSL
FQDQAEAQRRITFFAQSLSTPMPEVGPVHLMPSFTVLIPHYSEKITLSLREIIREEEQYS
HVTMLEYLKSLHPLEWSCFVKDTKLLAEEFETDSSSAEIKREKLDDLPYYSVGFKVATPE
YILRTRIWASLRSQTLYRTISGFMNYSRAIKLLFDVENPDSTKFGTENDKLEQAAIMAHR
KFRIITSMQRLKYFTPEEKENTEFLLRAYPELQICYLDEEVDEASGEIVYYSALVDGSCA
IMENGEREPKYRIRLSGNPILGDGKSDNQNHSLIFCRGEYIQLVDANQDNYLEECLKIRS
ILAEFEEATFPLDPYSTDLEGTESVYPVAIIGTREYIFSENIGILGDVAAGKEQTFGTLF
ARTLAHIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNVVLRGGRIKHCE
YMQCGKGRDLGFGSILNFTTKIGAGMGEQMLSREYFYMGTQLPLDRFLSFYYAHSGFHLN
NLFIMLSIHLFLLVGANLAALTSESTICEYDRFRPITDPKRPHGCYNLIPVVHWLQRCIF
SIFIVFVISFVPLAVQELTERGFYKAITRLGKQFASFSPLFEVFVCKIYAHSLSSDISIG
GARYLATGRGFATIRVPFATLYSRFAVESLYYGSICGLLIFYCSLSMWKLQLLYFWITIL
GLLICPFLYNPNQFSWNDFFLDYKECIQWFYRGNSKPRLSSWINFTRLKRSRIVGVKSKR
YSINEEIKVVSEVKPSRFKLIISESFLQLCVITLVGLAYLFTNSQNGSRGTYPVNSILRI
LIISFVPIGVNLVILIACFVVSISIGPIFTLFCKKFPSFVAAIAHLLAVANHVFFFELLW
LFQNWNFSVTVLGFALSALIQCWFLQMMTILLVSREFRHDRSNRSWWSGKWATAGLGWYI
ITQPMREAVCKLSEMSYFAGDLVATHIILFAQIPILLIPYADKWHTLMLFWLKPGNQIRP
RILSKRQKRRRRFQANLYLLIFLLGLILFSSIFVLPLIATKYFDIEFSEYIPEFFHPLFQ
PYDAPTNSKGLKKKLEIKHY
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BDBM50478215 |
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n/a |
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Name | BDBM50478215 |
Synonyms: | CHEBI:474180 | Cancidas | Caspofungin | Caspofungin Acetate | L-743,872 | L-743872 | MK-991 |
Type | Small organic molecule |
Emp. Form. | C52H88N10O15 |
Mol. Mass. | 1093.3131 |
SMILES | [H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](NCCN)NC(=O)[C@]1([H])[C@@H](O)CCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@H](O)CCN)NC(=O)CCCCCCCCC(C)CC(C)CC)[C@@H](C)O |r| |
Structure |
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