| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50028307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139742 |
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| IC50 | 45000±n/a nM |
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| Citation |  Griffith, RC; Gentile, RJ; Robichaud, RC; Frankenheim, J cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a] isoquinoline: a new atypical antidepressant. J Med Chem27:995-1003 (1984) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 60161.80 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 |
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| Residue: | 531 |
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| Sequence: | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQL
KTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL
LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPD
ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKK
REPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVT
TCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKY
FLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPN
LSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY
WLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50028307 |
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| n/a |
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| Name | BDBM50028307 |
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| Synonyms: | CHEMBL6575 | cis-2-Methyl-10-nitro-7-(4-nitro-phenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O4 |
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| Mol. Mass. | 368.3865 |
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| SMILES | CN1CCN2CC(c3ccc(cc3)[N+]([O-])=O)c3ccc(cc3C2C1)[N+]([O-])=O |
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| Structure | 
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