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Target | 1,3-beta-glucan synthase |
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Ligand | BDBM50478216 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_731119 (CHEMBL1697525) |
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IC50 | 99.4±n/a nM |
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Citation | Garcia-Effron, G; Lee, S; Park, S; Cleary, JD; Perlin, DS Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint. Antimicrob Agents Chemother53:3690-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,3-beta-glucan synthase |
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Name: | 1,3-beta-glucan synthase |
Synonyms: | 1,3-beta-glucan synthase component FKS1 | Beta-1,3-glucan synthase catalytic subunit | FKS1 |
Type: | PROTEIN |
Mol. Mass.: | 213936.94 |
Organism: | Candida glabrata |
Description: | ChEMBL_118415 |
Residue: | 1863 |
Sequence: | MSYNNNGQQMSDQGYYDNNQGYYQPEDQQNGQAMYGDEGYYDPNISGGDYYNQPPPPPNM
MGQDMENFSDFSSYGPPGVQGYDYQNMNQSGQYTPSQMSYNGDPNSGSSTPIYGNGMSAY
DPNAIAMALPNDPYPAWTADSQSPVPIEQIEDVFIDLTNKFGFQRDSMRNMFDHFMTLLD
SRTSRMAPDQALLSLHADYIGGDTANYKKWYFAAQLDMDDEVGFRNMSLGKLSRKARKAK
KKNKKAMEEANPEDAEDILNKLEGDNSLEAADFRWKTKMNALTPIERVRQIALYLLIWGE
ANQVRFTSECLCFIYKCATDYLNSPLCQQRTEPMPEGDYLNRVITPLYRFIRNQVYEIVD
GRYVKREKDHHKVIGYDDVNQLFWYPEGIAKIVFEDSTKLIEIPAEERYLRLGEVSWDDV
FFKTYKETRSWFHMITNFNRIWIMHVTIFWMYVAYNSPTFYTHNYQQLVNNQPPAAYKWA
SAALGGTVASFIQLLATICEWSFVPRKWAGAQHLSRRFWFLCLIFAVNLGPIIFVFAYEK
DTVQSKAGHAVAAVMFFVAVATLLFFSVMPLGGLFTSYMQKSTRRYVASQTFTASFAPLH
GLDRWLSYLVWVTVFAAKYAESYYFLILSLRDPIRILSTTTMRCTGEYWWGSKLCRHQSK
IVLGLMIATDFILFFLDTYLWYIVVNTVFSVGKSFYLGISILTPWRNIFTRLPKRIYSKI
LATTDMEIKYKPKVLISQVWNAIIISMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPT
FFVSQDDNNFETEFFPRNSEAERRISFFAQSLATPMPEPLPVDNMPTFTVLTPHYAERIL
LSLREIIREDDQFSRVTLLEYLKQLHPVEWECFVKDTKILAEETAAYEGMDDQDPEKEDA
LKNQIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENP
EIVQMFGGNAEGLERELEKMARRKFKFLVSMQRLAKFKPHELENAEFLLRAYPDLQIAYL
DEEPPLNEGEEPRIYSALIDGHCEILENGRRRPKFRVQLSGNPILGDGKSDNQNHALIFY
RGEYIQLIDANQDNYLEECLKIRSVLAEFEELNAEQVYPYSPGVKYEDQNTNHPVAIVGA
REYIFSENSGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFINATFMTTRGGISKA
QKGLHLNEDIYAGMNALLRGGRIKHCEYYQCGKGRDLGFGTILNFTTKIGAGMGEQMLSR
EYYYLGTQLPIDRFLTFYYAHPGFHLNNLFIQLSLQMFMLTLVNLHALAHESIICIYDKN
KPKTDVLYPIGCYNFSPAIDWVRRYTLSIFIVFWIAFVPIVVQELIERGLWKATQRFFRH
ILSLSPMFEVFAGQIYSSALLSDLTVGGARYISTGRGFATSRIPFSILYSRFAGSAIYMG
ARSMLMLLFGTVAHWQAPLLWFWASLSALLFSPFIFNPHQFSWEDFFLDYRDYIRWLSRG
NSKYHRNSWIGYVRMARSRITGFKRKLVGDESEKAAGDASRAHRTNLILAEIIPNAIYAA
GCFVGFTFINAQTGVKTTDDDRVNSVLRIIICTLAPIVIDIGVLFFVLGMSCCSGPLFGM
CCKRTGSVMAGFAHGIAVIVHIGFFIVMWVLEGFNFTRMLLGVVTMIQCQRLIFQCMTVL
MLTREFKNDHANTAFWTGKWYGSGFGYMAWTQPTRELTAKVIELSEFAADFVLGHVILFA
QFPVLCIPAIDKFHSIMLFWLKPSRQIRPPIYSLKQSRLRKRMVKRYLTLYIIVFLVFAG
CIVGPAVASSHVAKDLGHQLTGTFHNLVQPRNVSNNDTGFGISTYSNHYYTHTPSLKTWS
TIK
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BDBM50478216 |
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n/a |
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Name | BDBM50478216 |
Synonyms: | CHEBI:600520 | Micafungin | Mycamine |
Type | Small organic molecule |
Emp. Form. | C56H71N9O23S |
Mol. Mass. | 1270.274 |
SMILES | [H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](O)NC(=O)[C@]1([H])[C@@H](O)[C@@H](C)CN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)c(OS(O)(=O)=O)c1)[C@H](O)CC(N)=O)NC(=O)c1ccc(cc1)-c1cc(on1)-c1ccc(OCCCCC)cc1)[C@@H](C)O |
Structure |
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