| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-binding cassette sub-family C member 2 |
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| Ligand | BDBM50206509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_836171 (CHEMBL2075070) |
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| Ki | 44600±n/a nM |
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| Citation |  Horikawa, M; Kato, Y; Tyson, CA; Sugiyama, Y The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet17:23-33 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-binding cassette sub-family C member 2 |
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| Name: | ATP-binding cassette sub-family C member 2 |
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| Synonyms: | ATP-binding cassette sub-family C member 2 | Abcc2 | Canalicular multidrug resistance protein | Canalicular multispecific organic anion transporter 1 | Cmoat | Cmrp | MRP2_RAT | Mrp2 | Multidrug resistance-associated protein 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 173415.22 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1455464 |
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| Residue: | 1541 |
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| Sequence: | MDKFCNSTFWDLSLLESPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYSVYRSRTKRSSI
TKFYLAKQVFVVFLLILAAIDLSLALTEDTGQATVPPVRYTNPILYLCTWLLVLAVQHSR
QWCVRKNSWFLSLFWILSVLCGVFQFQTLIRALLKDSKSNMAYSYLFFVSYGFQIVLLIL
TAFSGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSK
FEAAMTKDLQKARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKD
YPKSWLIKSLFKTFHVVILKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICA
ILMFAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLM
SVDSQKLMDATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKI
RNIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQS
LLIFILQITPILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSIL
QASVSVDRLERYLGGDDLDTSAIRRVSNFDKAVKFSEASFTWDPDLEATIQDVNLDIKPG
QLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSE
YNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYIL
DDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGS
YRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMR
RENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKF
SIYLKYLQAVGWWSILFIILFYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRI
GVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRF
SGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVAT
SRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSN
RWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAET
NIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNI
KSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDP
ILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQL
LCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKI
MVLDNGKIVEYGSPEELLSNRGSFYLMAKEAGIENVNHTEL
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| BDBM50206509 |
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| n/a |
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| Name | BDBM50206509 |
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| Synonyms: | 4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfamoyl-benzoic acid anion | 4-Dipropylsulfamoyl-benzoic acid(probenecid) | Benemid | CHEMBL897 | PROBENECID | Probalan |
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| Type | Small organic molecule |
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| Emp. Form. | C13H19NO4S |
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| Mol. Mass. | 285.359 |
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| SMILES | CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O |
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| Structure | 
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