Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50043852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209590 (CHEMBL814725) |
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IC50 | 49±n/a nM |
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Citation | Soyka, R; Heckel, A; Nickl, J; Eisert, W; Müller, TH; Weisenberger, H 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors. J Med Chem37:26-39 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50043852 |
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n/a |
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Name | BDBM50043852 |
Synonyms: | (E)-6-(4-{2-[Carbamoylmethyl-(4-chloro-benzenesulfonyl)-amino]-ethyl}-phenyl)-6-pyridin-3-yl-hex-5-enoic acid | CHEMBL126196 |
Type | Small organic molecule |
Emp. Form. | C27H28ClN3O5S |
Mol. Mass. | 542.046 |
SMILES | NC(=O)CN(CCc1ccc(cc1)C(=C/CCCC(O)=O)\c1cccnc1)S(=O)(=O)c1ccc(Cl)cc1 |
Structure |
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