| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urease subunit beta |
|---|
| Ligand | BDBM50498385 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1505976 (CHEMBL3595644) |
|---|
| IC50 | 45100±n/a nM |
|---|
| Citation |  Xiao, ZP; Shi, WK; Wang, PF; Wei, W; Zeng, XT; Zhang, JR; Zhu, N; Peng, M; Peng, B; Lin, XY; Ouyang, H; Peng, XC; Wang, GC; Zhu, HL Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors. Bioorg Med Chem23:4508-4513 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urease subunit beta |
|---|
| Name: | Urease subunit beta |
|---|
| Synonyms: | 3.5.1.5 | URE1_HELPY | Urea amidohydrolase subunit beta | Urease subunit beta | hpuB | ureB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61676.43 |
|---|
| Organism: | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
|---|
| Description: | ChEMBL_117195 |
|---|
| Residue: | 569 |
|---|
| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPANKVSLAQLFSIF
|
|
|
|---|
| BDBM50498385 |
|---|
| n/a |
|---|
| Name | BDBM50498385 |
|---|
| Synonyms: | CHEMBL3594261 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H12N2O4 |
|---|
| Mol. Mass. | 260.2454 |
|---|
| SMILES | Oc1ccc(CNc2ccccc2[N+]([O-])=O)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
