| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
|---|
| Ligand | BDBM50049764 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_52076 (CHEMBL666526) |
|---|
| IC50 | 21000±n/a nM |
|---|
| Citation |  Wächter, GA; Hartmann, RW; Sergejew, T; Grün, GL; Ledergerber, D Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17. J Med Chem39:834-41 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B2, mitochondrial |
|---|
| Name: | Cytochrome P450 11B2, mitochondrial |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57582.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19099 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
|
|
|
|---|
| BDBM50049764 |
|---|
| n/a |
|---|
| Name | BDBM50049764 |
|---|
| Synonyms: | 2-[1-Pyridazin-3-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one | CHEMBL166709 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12N2O |
|---|
| Mol. Mass. | 236.2686 |
|---|
| SMILES | O=C1\C(CCc2ccccc12)=C\c1cccnn1 |
|---|
| Structure | 
|
|---|
Search and Browse
