| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-beta |
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| Ligand | BDBM50060972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1808821 (CHEMBL4308180) |
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| EC50 | 13000±n/a nM |
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| Citation |  Pollinger, J; Schierle, S; Gellrich, L; Ohrndorf, J; Kaiser, A; Heitel, P; Chaikuad, A; Knapp, S; Merk, D A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS Med Chem Lett10:1346-1352 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-beta |
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| Name: | Retinoic acid receptor RXR-beta |
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| Synonyms: | NR2B2 | Nuclear receptor subfamily 2 group B member 2 | RXRB | RXRB_HUMAN | Retinoic acid receptor RXR-beta | Retinoid X receptor beta | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56932.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_39045 |
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| Residue: | 533 |
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| Sequence: | MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
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| BDBM50060972 |
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| n/a |
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| Name | BDBM50060972 |
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| Synonyms: | 3',5'-Dichloro-biphenyl-4-carboxylic acid | CHEMBL106590 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H8Cl2O2 |
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| Mol. Mass. | 267.107 |
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| SMILES | OC(=O)c1ccc(cc1)-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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