| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50503692 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1811453 (CHEMBL4310913) |
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| IC50 | 6700±n/a nM |
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| Citation |  Luckhurst, CA; Aziz, O; Beaumont, V; Bürli, RW; Breccia, P; Maillard, MC; Haughan, AF; Lamers, M; Leonard, P; Matthews, KL; Raphy, G; Stott, AJ; Munoz-Sanjuan, I; Thomas, B; Wall, M; Wishart, G; Yates, D; Dominguez, C Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg Med Chem Lett29:83-88 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50503692 |
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| n/a |
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| Name | BDBM50503692 |
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| Synonyms: | CHEMBL4437833 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16FN3O2 |
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| Mol. Mass. | 337.3476 |
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| SMILES | Cc1ncc(cn1)-c1ccc(cc1)C(C(=O)NO)c1ccccc1F |
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| Structure | 
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