| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
|---|
| Ligand | BDBM50503791 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1812154 (CHEMBL4311614) |
|---|
| Kd | 12±n/a nM |
|---|
| Citation |  Va?kevi?ien?, I; Paketuryt?, V; Pajanok, N; ?ukauskas, ?; Sapijanskait?, B; Kantminien?, K; Mickevi?ius, V; Zubrien?, A; Matulis, D Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases. Bioorg Med Chem27:322-337 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 12 |
|---|
| Name: | Carbonic anhydrase 12 |
|---|
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39456.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 354 |
|---|
| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
|---|
| BDBM50503791 |
|---|
| n/a |
|---|
| Name | BDBM50503791 |
|---|
| Synonyms: | CHEMBL4570038 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16BrN3O4S |
|---|
| Mol. Mass. | 438.296 |
|---|
| SMILES | NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccc(Br)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
