| Reaction Details |
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 | Report a problem with these data |
| Target | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Ligand | BDBM50505422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1822731 (CHEMBL4322495) |
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| IC50 | 409±n/a nM |
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| Citation |  Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem62:8609-8630 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Target of rapamycin complex 2 subunit MAPKAP1 |
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| Name: | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Synonyms: | MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59129.70 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119716 |
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| Residue: | 522 |
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| Sequence: | MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
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| BDBM50505422 |
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| n/a |
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| Name | BDBM50505422 |
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| Synonyms: | CHEMBL4562100 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N6O2 |
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| Mol. Mass. | 382.4594 |
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| SMILES | [H][C@]12Cc3c(nc(nc3N3CCOCC3(C)C)-c3ccc(N)nc3)N1CCOC2 |r| |
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| Structure | 
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