| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Target of rapamycin complex subunit LST8 |
|---|
| Ligand | BDBM50505424 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1822732 (CHEMBL4322496) |
|---|
| IC50 | 2520±n/a nM |
|---|
| Citation |  Borsari, C; Rageot, D; Dall'Asen, A; Bohnacker, T; Melone, A; Sele, AM; Jackson, E; Langlois, JB; Beaufils, F; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. J Med Chem62:8609-8630 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Target of rapamycin complex subunit LST8 |
|---|
| Name: | Target of rapamycin complex subunit LST8 |
|---|
| Synonyms: | G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35871.25 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_118692 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
|
|
|
|---|
| BDBM50505424 |
|---|
| n/a |
|---|
| Name | BDBM50505424 |
|---|
| Synonyms: | CHEMBL4542182 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H26N6O3 |
|---|
| Mol. Mass. | 398.4588 |
|---|
| SMILES | [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3OC)N1CCOC2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
