| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50506000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824642 (CHEMBL4324406) |
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| IC50 | >100000±n/a nM |
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| Citation |  Chen, D; Li, L; Diaz, K; Iyamu, ID; Yadav, R; Noinaj, N; Huang, R Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide J Med Chem62:10783-10797 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM50506000 |
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| n/a |
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| Name | BDBM50506000 |
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| Synonyms: | CHEMBL4445337 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N8O6 |
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| Mol. Mass. | 524.5291 |
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| SMILES | N[C@@H](CCN(CC#Cc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| |
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| Structure | 
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